Four letters with two turns
Trace KNOT from K at row 2, column 3 to N at row 2, column 2, then O at row 3, column 2, and T at row 3, column 1. Move left, down, then left again; every move changes direction.
This four-cell route spans two rows and three columns. Check both turns rather than looking for a straight run of letters. Only the final cell touches the board's edge, and no corner is used. Once you have checked this entry, four cells are assigned and 40 remain.